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As noted in the press release, a recent 2012 study by the IMS Institute for Healthcare Informatics has identified six levers that can be applied to improve medicine use worldwide and empower public and private stakeholders to realize nearly a half-trillion dollar avoidable cost opportunity. The levers are: --Increase medicine adherence by addressing patient beliefs and behaviors at the point of prescription and during medicine intake. --Ensure timely medicine use that prevents avoidable and costly consequences among patients with highly prevalent diseases that increase in severity if diagnosis and treatment are delayed. --Optimize antibiotic use to turn the tide on rising antimicrobial resistance worldwide due to the misuse and overuse of antibiotics. --Prevent medication errors throughout the medicine provision pathway, from prescription to administration. --Use low-cost and safe generic drugs where available to leverage the under-exploited opportunity in post-patent expiry markets. --Manage polypharmacy where the concurrent use of multiple medicines, particularly among the elderly, risks costly complications and adverse events. --Improvements in patient adherence make up more than half – $269 billion – of the $500 billion annual opportunity in avoidable healthcare costs. The study also focuses on two key factors critical to driving improvement across the six levers: multi-stakeholder engagement, and the power of information. Prescribers, dispensers, the pharmaceutical industry and patients can all play a role in aligning the health system to drive improvement. The study, "Advancing the Responsible Use of Medicines: Applying Levers for Change, " released in October 2012, can be downloaded from: http://www.responsibleuseofmedicines.org/press-release-october-23-2012/