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HIV/AIDS

2012, une année charnière pour le sida et les avancées attendues

David Wilson's picture

Lors de la dernière conférence internationale sur le sida organisée à Washington, en 1987, les États-Unis étaient présidés par Ronald Reagan, l’Union soviétique tenait encore debout, un mur coupait Berlin en deux et la taille de l’économie chinoise était comparable à celle de l’Espagne. Personne n’aurait pu prédire les évolutions de notre planète ni celle de l’épidémie de sida.

 

En cette année 2012 décisive, la conférence est de retour à Washington. Le sida reste le plus grave défi de notre temps sur le front des maladies infectieuses, avec plus de 65 millions de contaminations et 30 millions de décès depuis le début de la pandémie, sans compter les quelque 3 millions de nouveaux cas et les 2 millions de victimes supplémentaires chaque année.

 

Ces statistiques sinistres ne doivent pas masquer les incroyables progrès accomplis. Lors de la conférence de 1987, le monde était démuni face à cette pandémie mortelle alors qu’il n’existait aucun médicament pour atténuer une lente et douloureuse agonie. Aujourd’hui, la palette des outils de prévention à l’efficacité avérée ne cesse de s’étoffer ; les infections sont en recul dans plus de 33 pays ; et jamais l’humanité n’a disposé d’autant de traitements pour lutter contre un virus. Les coûts de traitement annuels ont été divisés par 100 et ils atteignent désormais 8 millions de personnes à travers le monde, soit 60 fois plus. C'est, à ce jour, l'expansion la plus importante d'un traitement qui permet de sauver des vies.

 

Avec l’accélération des progrès scientifiques, des percées encore plus spectaculaires sont attendues.

 

C’est en Afrique surtout que ces progrès incroyables sont le plus visibles. En Afrique de l’Est et en Afrique australe, l’épidémie de sida était responsable à son paroxysme de 50 à 70 % des hospitalisations et des deux tiers des décès dans la population adulte. Imaginez un instant ce que cela signifierait à l’échelle de votre quartier. Dans mon pays, le Zimbabwe, les hôpitaux étaient remplis de mourants décharnés, le personnel soignant transformé en fossoyeurs, les hôpitaux en hospices et toute la vie sociale réduite à deux activités : visites aux malades et funérailles. Les marchands de cercueils, à l’activité florissante, s’installaient le long des routes menant aux cimetières surchargés.

AIDS 2012: In a watershed year, breakthroughs await

David Wilson's picture

When the International AIDS Conference was last held in Washington, D.C. in 1987, Ronald Reagan was U.S. president, the Soviet Union stood, a wall scarred a divided Berlin and China’s economy was roughly the size of Spain’s. The wider world – and the AIDS epidemic – has changed more than anyone foresaw.

 

The conference returns to Washington in a watershed year. AIDS remains the greatest infectious disease challenge of our age: more than 65 million people infected and 30 million deaths since the epidemic began, and roughly 3 million new infections and 2 million deaths a year.

 

These are grim statistics, but they belie the incredible progress made. When we met at the 1987 AIDS conference, the world had few tools to prevent deadly infections and no drugs to commute slow, agonizing, wasting death. Today, there is an expanding armory of proven prevention tools; new HIV infections have been reduced in more than 33 countries; and there are more drugs to treat HIV than for every retrovirus in history combined.  Annual treatment costs have been reduced 100-fold and AIDS treatment has been expanded 60-fold to reach 8 million people worldwide in the largest-ever expansion of lifesaving treatment.

 

As the pace of scientific progress accelerates, even greater breakthroughs await us.

 

Nowhere is this amazing progress more evident than in Africa. At its peak in Eastern and Southern Africa, AIDS was responsible for 50-70% of bed occupancy and two-thirds of all adult deaths. Let each of us simply try to imagine experiencing this in our own neighborhoods. In my country, Zimbabwe, hospitals overflowed with emaciated, dying people, nurses and doctors were undertakers, hospitals were hospices, and an entire society’s social life rotated from hospital beds to funeral gravesides. Coffin-making was the fastest growing business, lining miles of roads to overcrowded cemeteries.

Transitions in financing HIV/AIDS programs

Patrick Osewe's picture

(Portrait of mother and child. Botswana. Photo: Curt Carnemark / World Bank)

While participating in a study of HIV spending efficiency in South Africa, I met a young HIV-positive mother who had just received the joyful news that her new-born daughter was healthy and HIV-free. Wiping away tears of relief, she described the gratitude she felt for the antenatal clinic staff, who had helped start her on antiretroviral treatment (ART) and thanks to whom she now had the hope of a bright future for her daughter. This encounter was just one among many similar incidents during the study – and, as our preliminary data show, is representative of the positive impact of the Government’s strong commitment to bringing down rates of HIV.

 

South Africa has mounted one of the strongest responses to HIV in the world. Its most dramatic success has been the scale-up of ART since 2003, growing from almost nothing to the country’s largest health program that treated about 1.5 million people in 2011 (out of a total HIV-infected population of 5.6 million).

 

The impacts of this treatment drive are already showing, with overall mortality, maternal and infant deaths all on a downward trend following their HIV-related peaks in the early-to mid-2000s. However, the cost of sustaining this success is huge: South Africa has committed to putting an estimated target of almost 10% of the entire population on a life-long course of expensive drug treatment. And, even with government negotiators bringing down ART drug prices by 65% since 2008, successful testing campaigns coupled with the worrying increase in resistance to first-line therapies look set to further raise the financial risk.

 

These challenges extend beyond South Africa. An analysis of the fiscal dimensions of HIV/AIDS released by the World Bank earlier this year in a number of countries concluded that without significant additional investments in prevention starting now, the cost of treatment will rapidly become unaffordable for even the most cash-rich countries on the African continent.

Circumcision and smoking bans: Can policies nudge people toward healthy behaviors?

Patricio V. Marquez's picture

Walking through river. Mali. Photo: © Curt Carnemark / World Bank

The scaling up of voluntary medical male circumcision, particularly in high HIV prevalence settings, is a highly cost-effective intervention to fight the epidemic—randomized controlled trials have found a 60% protective effect against HIV for men who became circumcised.

But, the supply of this medical service is just one part of the picture. Without active involvement from individuals and communities to deal with social and cultural factors that influence service acceptability, the demand for this common surgical procedure will be low.

Indeed, on a recent visit to Botswana, a country with high HIV prevalence and low levels of male circumcision, my World Bank colleagues and I had a good discussion with the National HIV/AIDS Commission about ways to address the low uptake of voluntary, safe male circumcision services in spite of a well-funded program by the government.  It was obvious to all that if the demand for, and uptake of, this service were not strengthened through creative mechanisms that foster acceptance, ownership, and active participation of individuals and community organizations, the program would not help control the spread of HIV through increased funding of facilities, equipment, and staff alone.

So, what do we need to do to ensure that need, demand, utilization, and supply of services are fully aligned to improve health conditions?

Southern Africa's TB challenge migrates with miners

Patrick Osewe's picture

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A while ago, I was part of a mission to visit a new hospital in Lesotho. Warned in advance that this facility was intended to treat people with multi-drug resistant tuberculosis (TB)– and knowing the huge burden of HIV-TB co-infection in the country—I was expecting the patients’ demographic to match the profile of HIV: largely young and increasingly female.

What I wasn’t prepared for was the sight of two entire families—young and old, men, women and children—all confined together for the foreseeable future, to be monitored by health workers as they take their daily drugs.

'All People Want to Do Is Live Their Lives'

Elizabeth Howton's picture

"All people want to do is live their lives." Dr. Suneeta Singh made that simple yet powerful statement during a panel discussion on “Empowering Gender Minorities in South Asia” on March 14, 2012 at the World Bank. Singh, a former Bank staffer and CEO of consulting firm Amaltas, spoke via videoconference from Delhi, India, while Nepal’s first openly gay elected official, Sunil Babu Pant, dialed in from Kathmandu.World Bank panel discussion on gender indentity in South Asia

Pant told the story of how he built a grassroots movement of gay, lesbian, bisexual and transgendered (GLBT) people in Nepal, beginning in 2001. A turning point was in 2007, when the Supreme Court ruled that gay and transgendered people “are natural” and mandated certain benefits and an end to discriminatory laws. Today, the country is drafting a new constitution, and Pant said that if passed, it will be one of the most progressive in the world with regard to the rights of sexual and gender minorities.

'All People Want to Do Is Live Their Lives'

Elizabeth Howton's picture

World Bank panel discussion on gender identity in South Asia Dr. Suneeta Singh made that simple yet powerful statement during a panel discussion on “Empowering Gender Minorities in South Asia” on March 14, 2012 at the World Bank. Singh, a former Bank staffer and CEO of consulting firm Amaltas, spoke via videoconference from Delhi, India, while Nepal’s first openly gay elected official, Sunil Babu Pant, dialed in from Kathmandu.

Pant told the story of how he built a grassroots movement of gay, lesbian, bisexual and transgendered (GLBT) people in Nepal, beginning in 2001. A turning point was in 2007, when the Supreme Court ruled that gay and transgendered people “are natural” and mandated certain benefits and an end to discriminatory laws. Today, the country is drafting a new constitution, and Pant said that if passed, it will be one of the most progressive in the world with regard to the rights of sexual and gender minorities.

AIDS: translating scientific discoveries into sustainable, affordable programs

David Wilson's picture

Red ribbon for World AIDS Day, Thailand (credit: Trinn Suwannapha).

We’re entering a phase where AIDS is moving from emergency crisis financing to sustainable development financing—which is a major challenge, but one that we’re continuing to tackle, with the goal of stronger national ownership and responsibility.

 

One of the Bank’s international mandates is to support countries to develop better national health plans and budgets. Today, the Bank released an important study, The Fiscal Dimension of HIV/AIDS in Botswana, South Africa, Swaziland, and Uganda, which is a part of this mandate. The study helps countries do the long-range planning that we so desperately need in HIV programs.

 

The Bank has a long-established partnership with ministries of finance and planning, and we understand country systems. We stand ready to help countries integrate HIV into their programs and plan for it in a sustainable way.

 

We’ve seen extraordinary progress in AIDS. Today, we have more antiretroviral drugs to treat HIV than every other virus in history combined. We’ve reduced treatment costs from tens of thousands of dollars to as little as $100. And we’ve expanded our understanding of effective HIV prevention, including the role of male circumcision and the important role that treatment can play in prevention under the right circumstances.

 

Many of us involved in HIV remember the days when 70% of beds in health facilities in Africa were occupied by people with AIDS. Our successes in treatment and prevention have removed this specter and have allowed health systems to focus on other important health priorities.

Professional Hazard: Migrant Miners Are More Likely to Be Infected with HIV

Damien de Walque's picture

Gold mine in Johannesburg, South AfricaSwaziland and Lesotho are among the countries with the highest HIV prevalence in the world.
Recent nationally representative estimates reveal an adult HIV prevalence equal to 26% in Swazilandand 23.2% in Lesotho2.

These countries have two other main features in common: they are small countries bordering South Africa and, during the past decades, they were exposed to massive recruitment efforts to work in South African mines. For more than a century, about 60 percent of those employed in the mining sector in the Republic of South Africa were migrant workers from Lesotho and Swaziland3.

In a recent paper4 with Lucia Corno, we started from this set of facts and investigated whether the massive percentage of migrant workers employed in the South Africa’s mining industry for a long period might be one of the main explanations for the high HIV prevalence observed in Swaziland and Lesotho.

A New Mechanism for South-South Knowledge

Susana Carrillo's picture

In my previous blog entry, I mentioned the expected growing engagement between Brazil and Sub-Saharan African countries in 2012, to exchange knowledge and further economic and social development.


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