The role of entrepreneurs in job creation has a long intellectual tradition (Cantillion 1730, Knight 1921, Schumpeter 1942). While the great economic minds throughout history recognized the link between entrepreneurship, regional development, and job creation, controversies remain. Our understanding of entrepreneurship is still at an early stage (Glaeser et al 2009, Klapper and Love 2011). How does one quantify entrepreneurship? Do young/small establishments or large/established firms contribute to job growth? Have manufacturing or service sectors created more jobs? What is the geographical scale at which entrepreneurial mechanics function? Why do some cities attract more entrepreneurs? Do agglomeration economies and networking differ across formal and informal sectors and industries, cities, and gender? What makes some local governments fiscally more entrepreneurial than others? These questions provide insights into job creation and they have rightly attracted the attention of researchers, but many of them remain unanswered.